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For related content, visit: Lancet Global Health 2035 Commission: http://www.thelancet.com/commissions/global-health-2035 Lancet Planetary Health Commission: http://www.thelancet.com/commissions/planetary-health Richard Horton presents the 2015 Burnet Oration at the Burnet Institute in Melbourne, Oct 5, 2015. Copyright: The Burnet Institute